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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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White sponge nevus: a case report.

Amirala Aghbali¹, Firouz Pouralibaba, Hossein Eslami

¹Assistant Professor, Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Journal of Dental Research, Dental Clinics, Dental Prospects

|December 12, 2012

Summary

White sponge nevus (WSN), a rare hereditary condition, presents as dyskeratotic hyperplasia of mucous membranes. This case highlights WSN in a young male without family history, confirmed via histopathology.

Keywords:

Dyskeratosis white lesion white sponge nevus

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Area of Science:

Oral Medicine
Dermatology
Genetics

Background:

White sponge nevus (WSN) is a rare autosomal dominant disorder characterized by hereditary dyskeratotic hyperplasia of mucous membranes.
The condition exhibits variable penetrance, meaning not all individuals with the gene mutation display symptoms.

Observation:

A case study of a healthy 21-year-old male with no prior family history of the condition is presented.
Clinical examination revealed a white, smooth plaque on the oral mucosa without erythema or other abnormalities.

Findings:

Histopathological examination confirmed the diagnosis of White Sponge Nevus.
The findings align with the known characteristics of WSN, despite the lack of familial involvement.

Implications:

This case expands the understanding of WSN presentation, particularly in individuals without a known family history.
Highlights the importance of histopathological confirmation for diagnosing rare genetic conditions like WSN.
Underscores the variable penetrance and potential for sporadic occurrence of autosomal dominant disorders.