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Two distinct knockout approaches highlight a critical role for p53 in rat development

Masaki Kawamata1, Takahiro Ochiya

  • 1Division of Molecular and Cellular Medicine, National Cancer Center Research Institute , 1-1, Tsukiji, 5-chome, Chuo-ku, Tokyo 104-0045, Japan.

Scientific Reports
|December 12, 2012
PubMed
Summary

The tumor suppressor p53 is crucial for normal embryogenesis in rats, preventing developmental defects and maintaining genomic stability in embryonic stem cells (ESCs). Its absence leads to embryonic lethality and neural tube defects, particularly in females.

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