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Related Concept Videos

Overview of Transposition and Recombination02:13

Overview of Transposition and Recombination

Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Transposons01:24

Transposons

Transposons, or "jumping genes," are small mobile genetic elements (MGEs) that range from 700 to 40,000 base pairs in length. They are found in all organisms and can move within the same chromosome or transfer to different chromosomes. In some cases, transposons can also jump between different host DNA molecules, such as plasmids or viruses, contributing to genetic variability.Barbara McClintock first discovered these mobile genetic elements in the 1940s while studying maize genetics, and she...
Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
LTR Retrotransposons03:08

LTR Retrotransposons

LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less abundant in mammals compared to other class I transposable elements. About 8 percent of human genomic DNA comprises LTR retrotransposons. Some of the common examples of LTR retrotransposons are Ty elements in yeast and Copia elements in Drosophila.
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
Gene Duplication and Divergence02:37

Gene Duplication and Divergence

The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are characterized.

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Related Experiment Video

Updated: May 16, 2026

Identification of Footprints of RNA:Protein Complexes via RNA Immunoprecipitation in Tandem Followed by Sequencing (RIPiT-Seq)
09:26

Identification of Footprints of RNA:Protein Complexes via RNA Immunoprecipitation in Tandem Followed by Sequencing (RIPiT-Seq)

Published on: July 10, 2019

TRAP Sequence - An Interesting Entity in Twins.

R H Srinivas Prasad1, T Ramachandra Prasad, K Dayananda Kumar

  • 1Department of Radio-Diagnosis and Imaging, MVJ Medical, College and Research Hospital, Bangalore, Karnataka, India.

Journal of Clinical Imaging Science
|December 12, 2012
PubMed
Summary
This summary is machine-generated.

Twin reversed arterial perfusion (TRAP) sequence is a rare condition in identical twins. Early diagnosis with Doppler imaging is crucial for managing complications and improving outcomes for the pump twin.

Keywords:
Acardiac twinTRAP sequencecolor dopplerultrasound

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Last Updated: May 16, 2026

Identification of Footprints of RNA:Protein Complexes via RNA Immunoprecipitation in Tandem Followed by Sequencing (RIPiT-Seq)
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Area of Science:

  • Perinatology
  • Maternal-Fetal Medicine
  • Medical Imaging

Background:

  • Twin reversed arterial perfusion (TRAP) sequence is a rare complication of monochorionic multiple gestations.
  • It involves a normal "pump" twin and an acardiac, developmentally abnormal twin.
  • The acardiac twin is dependent on the pump twin's cardiovascular system.

Observation:

  • The acardiac twin often presents with severe anomalies incompatible with survival.
  • The pump twin faces significant risks, including congestive heart failure, prematurity, and polyhydramnios.
  • Mortality rates for the pump twin range from 50% to 70%.

Findings:

  • Gray-scale and color Doppler imaging are essential for accurate diagnosis of TRAP sequence.
  • These imaging techniques aid in identifying features indicative of poor prognosis.
  • Prompt diagnosis facilitates timely management strategies.

Implications:

  • Early detection and vigilant follow-up are critical for optimizing outcomes in TRAP sequence.
  • Effective management can mitigate risks to the pump twin.
  • This case series highlights the indispensable role of advanced imaging in managing this rare condition.