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Updated: May 16, 2026
Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro
Published on: April 15, 2022
[Progress of in vivo study on degradable magnesium alloys application as bone-implant materials]
Zhengrong Qi1, Qiang Zhang, Yi Yin
1Department of Orthopaedics, General Hospital of Chinese PLA, Beijing, 100853, P.R.China.
Objective:
To review the progress of in vivo study on degradable magnesium alloys application as bone-implant materials.
Methods:
Recent literature was extensively reviewed and summarized, concerning the in vivo study on degradable magnesium alloys as orthopaedic implants.
Results:
Magnesium alloys possess a natural ability to degrade via corrosion in vivo, which is promising candidate material for orthopaedic medical device applications. A great progress has been made to improve in vivo performance and integration with bone tissue. However, the degradation mechanism of magnesium-based materials in the physiological environment and long-term effect on body are not available. The modulation of the corrosion rate of magnesium alloys must also be accomplished.
Conclusion:
Magnesium alloys have the potential to serve as degradable implants for orthopaedic applications, but a great deal of further investigation is still necessary.
