Comprehensive assessment of the slice sensitivity profiles in breast tomosynthesis and breast CT

This study experimentally evaluated the slice sensitivity profile (SSP) and its relationship between acquisition angle, object size, and cone angle. The sensitivity profile metric was used to characterize a breast tomosynthesis system's resolution in the z-axis. The SSP was also measured on a prototype breast computed tomography (bCT) system.

The SSP was measured using brass disks placed within adipose tissue-equivalent breast phantoms. The digital tomosynthesis system (Selenia Dimensions, Hologic Corporation, Bedford, MA) acquires projection images over a 15° angular range and the bCT scanner acquires projection images over a 360° angular range. Angular ranges between 15° and 360° were studied by using a subset of the projection images acquired on the bCT scanner. The SSP was determined by measuring a background-corrected mean gray scale value as a function of the z-position (axis normal to the plane of the detector).

The results show that SSP improves when the angular acquisition range is increased and the SSP approaches a delta function for angles greater than 180°. Smaller objects have a narrower SSP and the SSP is not significantly dependent on the cone angle. For a 2.5, 5, 10 mm disk, the full width at half maximum of the SSP was 35, 61, 115 mm, respectively, on the tomosynthesis system (at 15°) and was 0.5 mm for all disk diameters on the bCT scanner (at 360°).

The SSP is dependent on object size and angular acquisition range. These dependencies are overcome once the angular acquisition range is increased beyond 180°.