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Related Concept Videos

Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...

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Related Experiment Video

Updated: May 16, 2026

Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature
11:40

Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature

Published on: April 1, 2014

Acute bacterial septic vasculopathy.

Yolanda Delgado-Jiménez1, Javier Fraga, Celia Requena

  • 1Department of Dermatology Pathology, Hospital Universitario de la Princesa (Princess University Hospital), Madrid, Spain. ydelgado@aedv.es

International Journal of Dermatology
|December 13, 2012
PubMed
Summary
This summary is machine-generated.

Cutaneous lesions in bacterial septic vasculopathy are common, presenting as purpura or petechiae. Histopathology reveals thrombo-occlusive vasculopathy, aiding early diagnosis and treatment.

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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

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Last Updated: May 16, 2026

Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature
11:40

Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature

Published on: April 1, 2014

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Pathology

Background:

  • Cutaneous manifestations of sepsis, particularly septic vasculopathy, are not well-characterized.
  • Understanding the clinicopathologic features of skin lesions in sepsis is crucial for diagnosis and management.

Purpose of the Study:

  • To analyze the clinical and histopathologic characteristics of cutaneous lesions in bacterial septic vasculopathy.
  • To compare findings between immunosuppressed patients (ISPs) and non-immunosuppressed patients (NISPs).

Main Methods:

  • Retrospective analysis of 32 patients with bacterial sepsis, cutaneous lesions, and biopsy-proven septic vasculopathy.
  • Evaluation of clinical presentation, skin biopsy findings, and comparison between ISPs and NISPs.

Main Results:

  • Cutaneous lesions, primarily purpuric and petechial, occurred early in 90.6% of patients.
  • Skin biopsies consistently showed thrombo-occlusive vasculopathy with thrombi; fibrinoid necrosis and bacterial invasion were more frequent in ISPs.
  • Mortality was 28.1%, with 65.5% surviving without sequelae.

Conclusions:

  • Septic vasculopathy can be caused by various microorganisms, presenting with variable clinical features.
  • Histopathologically, it is a thrombo-occlusive vasculopathy with diverse morphology.
  • Early cutaneous lesions are key diagnostic indicators for septic vasculopathy.