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Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
08:50

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Published on: March 26, 2018

Viewpoint: the ENIGMAS trial - when should we treat patients with moderate aortic stenosis?

Alexandru Nicolae Mischie1, Catalina Liliana Andrei, Crina Sinescu

  • 1Cardiology Department, "Bagdasar Arseni" Emergency Hospital, Bucharest, Romania. alexandru_mischie@yahoo.com

Echocardiography (Mount Kisco, N.Y.)
|December 13, 2012
PubMed

Insights

Moderate aortic stenosis (AS) presents a treatment challenge with higher mortality. This review summarizes progression factors and proposes optimal trial designs for moderate AS using advanced imaging techniques.

Area of Science:

  • Cardiology
  • Valvular Heart Disease
  • Medical Research

Background:

  • Aortic stenosis (AS) is the most common valvular heart disease.
  • Management guidelines exist for severe AS, but moderate AS lacks clear treatment pathways.
  • Patients with moderate AS exhibit increased mortality compared to age-matched individuals.

Purpose of the Study:

  • To review existing literature on moderate aortic stenosis.
  • To identify factors contributing to the progression of moderate AS.
  • To propose an optimal prospective trial design for evaluating AS progression.

Main Methods:

  • Comprehensive literature review of studies focusing on moderate AS.
  • Analysis of factors influencing disease progression.
  • Discussion of modern cardiology tools like strain imaging and magnetic resonance imaging for trial design.

Main Results:

  • Identified key factors that accelerate moderate AS progression.
  • Highlighted the need for better understanding and management strategies for moderate AS.
  • Outlined a framework for future research into AS progression.

Conclusions:

  • Moderate AS requires further investigation due to significant mortality risks.
  • Advanced imaging techniques are crucial for future AS progression studies.
  • Optimized trial designs are needed to evaluate progression factors and inform treatment.

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