Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Assessment of the Cardiovascular System III: Palpation01:27

Assessment of the Cardiovascular System III: Palpation

Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...
Hypodermis01:02

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Varicose Veins I: Introduction01:26

Varicose Veins I: Introduction

Varicose veins, or varicosities, are abnormally dilated and twisted superficial veins caused by venous valve incompetence. This condition commonly affects the lower extremities, especially the saphenous veins, due to the higher pressure from prolonged standing and walking. However, varicosities can also occur in other areas, such as the esophagus, vulva, spermatic cords, and anorectal region.Etiology and typesPrimary varicose veins, often idiopathic, are more common in women due to inherent...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Prospective Clinical Study to Confirm the Safety and Performance of a Canister-Based Single-Use Negative Pressure Wound Therapy System in Low-to-Moderately Exuding Chronic Wounds.

International wound journal·2026
Same author

No significant differences in ultrasound morphology after endovenous laser ablation with 1940-nm versus 1470-nm radially emitting fibers: A one-year prospective randomized multicenter study.

Phlebology·2026
Same author

A Novel 3D Semi-Automated Full Quantification Technique for Detection of Intraneural Phospho-α-Synuclein in Skin Biopsies.

European journal of neurology·2026
Same author

Same site recurrence following standardized high ligation and stripping of the great saphenous vein - 5-year results of the LaVaCro trial.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

[Postthrombotic syndrome: an update].

Dermatologie (Heidelberg, Germany)·2026
Same author

Validation of PARACELSUS score performance for the diagnosis of pyoderma gangrenosum: An international multicenter study with 1403 cases.

Journal of the American Academy of Dermatology·2026

Related Experiment Video

Updated: May 16, 2026

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema
05:44

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema

Published on: January 12, 2017

Thick legs - not always lipedema.

Stefanie Reich-Schupke1, Peter Altmeyer, Markus Stücker

  • 1Department of Dermatology, Venereology and Allergology, University of Bochum, Germany. s.reich-schupke@klinikum-bochum.de

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|December 13, 2012
PubMed
Summary

Lipedema, a rare condition causing disproportionate fat in legs and hips, is often misdiagnosed. Early diagnosis and conservative or surgical treatments are key, but a cure remains elusive.

Related Experiment Videos

Last Updated: May 16, 2026

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema
05:44

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema

Published on: January 12, 2017

Area of Science:

  • Medical Science
  • Dermatology
  • Vascular Medicine

Background:

  • Lipedema is a rare condition characterized by disproportionate fat distribution, primarily affecting the hips and legs.
  • Symptoms include easy bruising, and pain in affected areas, often exacerbated by pressure.
  • Increased media attention has led to a rise in diagnoses, but awareness of its rarity and distinct characteristics is crucial.

Purpose of the Study:

  • To clarify the diagnostic criteria and differential diagnoses for lipedema.
  • To outline current therapeutic approaches, including conservative and surgical options.
  • To emphasize the need for further research into lipedema's pathogenesis and potential cures.

Main Methods:

  • Diagnostic aids include duplex sonography, waist-hip index, waist-height index, and lymphoscintigraphy.
  • Differential diagnoses considered are constitutional leg shape, lipohypertrophy, edema from immobility or chronic venous insufficiency, and rheumatic diseases.
  • Therapeutic strategies involve conservative management (compression, manual lymphatic drainage, exercise) and surgical interventions (liposuction).

Main Results:

  • Lipedema is a rare disease, not a common cause of leg swelling.
  • Accurate diagnosis relies on specific clinical findings and imaging techniques.
  • Obesity is a significant factor influencing lipedema severity and prognosis.

Conclusions:

  • Lipedema requires careful differentiation from other conditions causing leg enlargement and pain.
  • Current treatments focus on symptom management, as no cure exists.
  • Further research is essential to understand lipedema's underlying mechanisms and develop effective treatments.