Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet function and serum high density lipoproteins.

A Nordøy, N Refsum, D Thelle

    Thrombosis and Haemostasis
    |December 21, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    R(3780) Resonance Interpreted as the 1^{3}D_{1}-Wave Dominant State of Charmonium from Precise Measurements of the Cross Section of e^{+}e^{-}→Hadrons.

    Physical review letters·2025
    Same author

    Precise Measurement of Born Cross Sections for e^{+}e^{-}→DD[over ¯] at sqrt[s]=3.80-4.95  GeV.

    Physical review letters·2024
    Same author

    First Observation of a Three-Resonance Structure in e^{+}e^{-}→Nonopen Charm Hadrons.

    Physical review letters·2024
    Same author

    Determination of Spin-Parity Quantum Numbers of X(2370) as 0^{-+} from J/ψ→γK_{S}^{0}K_{S}^{0}η^{'}.

    Physical review letters·2024
    Same author

    Observation of Structures in the Processes e^{+}e^{-}→ωχ_{c1} and ωχ_{c2}.

    Physical review letters·2024
    Same author

    Coupled-Channel Analysis of the χ_{c1}(3872) Line Shape with BESIII Data.

    Physical review letters·2024
    Same journal

    Discontinuation of Oral Anticoagulation After Successful Catheter Ablation for Atrial Fibrillation: Meta-analysis of Randomized Clinical Trials.

    Thrombosis and haemostasis·2026
    Same journal

    Novel/Recurrent Variants in Pakistani Glanzmann Thrombasthenia and Glanzmann-like bleeding diathesis: Insights from NGS Analysis.

    Thrombosis and haemostasis·2026
    Same journal

    Anti-TFPI Single-Domain Antibodies: Novel Rebalancing Therapies for Hemophilia and Other Rare Bleeding Disorders.

    Thrombosis and haemostasis·2026
    Same journal

    The Interaction of Fibrin with Endothelial Cell Receptor N-Cadherin Promotes Fibrin-Dependent Angiogenesis.

    Thrombosis and haemostasis·2026
    Same journal

    Antiphospholipid Antibodies and Atrial Fibrillation: Clinical Implications and the TaPL AF Study Design.

    Thrombosis and haemostasis·2026
    Same journal

    Prasugrel vs. Ticagrelor: Can TUXEDO-2 Settle the Debate?

    Thrombosis and haemostasis·2026
    See all related articles

    Low high density lipoprotein (HDL) cholesterol, a risk factor for coronary heart disease (CHD), was investigated for its effect on platelet function. While no direct differences in platelet function were found, HDL concentration positively correlated with platelet factor 3 activity.

    Area of Science:

    • Cardiovascular Science
    • Hematology
    • Lipid Metabolism

    Background:

    • Low high density lipoprotein (HDL) cholesterol is an established independent risk factor for coronary heart disease (CHD).
    • Platelet activation and function play a critical role in the pathogenesis of atherosclerosis and thrombosis.
    • The relationship between HDL cholesterol levels and platelet function requires further elucidation.

    Purpose of the Study:

    • To investigate the potential association between low plasma high density lipoprotein (HDL) cholesterol concentrations and alterations in in vitro platelet function.
    • To explore the correlation between plasma HDL levels and specific markers of platelet activity.

    Main Methods:

    • Comparison of platelet function tests between two groups of healthy males: one with low HDL (mean 1.03 mmol/l) and another with normal HDL (mean 1.80 mmol/l).

    Related Experiment Videos

  • In vitro assessment of various platelet function parameters.
  • Measurement of platelet factor 3 activity in both platelet-rich and platelet-poor plasma.

    • Main Results:

    • No significant differences in overall platelet function were observed between the low HDL and normal HDL groups.
    • A statistically significant positive correlation was identified between plasma HDL cholesterol concentration and platelet factor 3 activity.
    • This positive correlation was consistent in both platelet-rich and platelet-poor plasma samples.

    Conclusions:

    • Low plasma HDL cholesterol concentration, despite being a CHD risk factor, does not appear to directly impair in vitro platelet function in healthy males.
    • Plasma HDL cholesterol concentration shows a positive association with platelet factor 3 activity, suggesting a potential indirect relationship or a shared underlying mechanism.
    • Further research is warranted to understand the clinical implications of the observed correlation between HDL levels and platelet factor 3 activity in cardiovascular health.