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Updated: May 16, 2026
Amplitude-Integrated EEG in Infants at Risk of Hypoxic-Ischemic Encephalopathy: A Feasibility Study in Road and Air Transport in Western Australia
Published on: June 21, 2024
Prediction of neurodevelopmental outcome in term neonates with hypoxic-ischemic encephalopathy
Muzaffer Polat1, Ayşe Simşek, Nermin Tansuğ
1Celal Bayar University School of Medicine, Department of Pediatric Neurology, Manisa, Turkey.
Background:
Hypoxic ischemic encephalopathy may result in many neurological deficits. It is crucial to make early diagnosis and assess the prognosis correctly.
Aims:
We aimed to determine the factors to evaluate the prognosis of hypoxic ischemic encephalopathy.
Methods:
Electroencephalography, neuroimaging, periodic neurological exams and a developmental test at 44-48 months after discharge from the hospital were performed on twenty five term newborn infants with clinical evidence of hypoxic ischemic encephalopathy.
Results:
Normal/mildly abnormal neonatal electroencephalography correlated with favorable outcome, particularly if neuroimaging was normal. The cranial MRI sensitivity was 83.3%, while the specificity was 57.9%, the positive predictive value was 38.5%, and the negative predictive value was 91.6%. Moderate/severely abnormal electroencephalography and multifocal/diffuse cortical or deep gray matter lesions correlated with poor outcome.
Conclusions:
Newborn infants with hypoxic ischemic encephalopathy should be treated in neonatal intensive care units, assessed with periodic neurological examination, electroencephalogram and brain imaging. This would help to initiate early intervention and improve the outcome of patients.
