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Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
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Factors shaping physicians' willingness to accommodate medication requests.

Jennifer Arney1, Richard L Street2, Aanand D Naik3

  • 1Department of Sociology, University of Houston-Clear Lake, Houston, TX, USA Health Services Research and Development Center of Excellence, Michael E. DeBakey Department of Veterans Affairs Medical Center, Houston, TX, USA Department of Medicine-Section on Health Services Research, Baylor College of Medicine, Houston, TX, USA Arney@bcm.edu.

Evaluation & the Health Professions
|December 13, 2012
PubMed
Summary

Physicians are more likely to prescribe requested brand-name drugs when patients understand risks and have the condition. Primary care doctors accommodate requests more than specialists, influenced by clinical and communication factors.

Keywords:
patient-centered carepatient–provider relationshipsphysician behaviorprescribing patterns/practicesprimary care

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Area of Science:

  • Medical decision-making
  • Health services research
  • Pharmaceutical marketing

Background:

  • Physician prescribing behaviors are influenced by clinical and nonclinical factors.
  • Direct-to-consumer advertising impacts medical encounters and physician-patient interactions.

Purpose of the Study:

  • To investigate how physician, patient, and relationship characteristics influence accommodating brand-name prescription drug requests.
  • To analyze factors affecting physicians' decisions regarding patient-initiated medication requests.

Main Methods:

  • Multivariate logistic regression analysis.
  • Utilized data from the Attitudinal and Behavioral Effects of Direct-to-Consumer Promotion of Prescription Drugs physician survey.
  • National probability sample of 500 primary care and specialty physicians.

Main Results:

  • Physicians were more inclined to prescribe when patients understood medication risks and had the indicated condition.
  • Primary care practitioners showed higher accommodation rates for requested drugs compared to specialists.
  • Physician's assessment of patient understanding and condition appropriateness were key predictors.

Conclusions:

  • Clinical and communication factors significantly shape physicians' decisions on prescribing requested brand-name drugs.
  • Findings highlight the impact of direct-to-consumer advertising on prescription patterns.
  • Results can inform strategies to improve physician-patient communication and shared decision-making.