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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...

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Related Experiment Video

Updated: May 16, 2026

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
10:37

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Published on: October 20, 2021

Patient preferences for hepatitis B therapy.

Seng Gee Lim1, Myat Oo Aung, Stephanie W M Chung

  • 1Department of Gastroenterology and Hepatology, National University Health System, Singapore. mdclimsg@nus.edu.sg.

Antiviral Therapy
|December 13, 2012
PubMed
Summary

Patient preferences significantly influence chronic hepatitis B (CHB) treatment choices. Efficacy and oral, once-daily dosing are key, with entecavir being the preferred drug among surveyed patients.

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Area of Science:

  • Hepatology
  • Patient-centered care
  • Pharmacoeconomics

Background:

  • Limited understanding of patient preferences in chronic hepatitis B (CHB) treatment selection.
  • Patient preferences impact therapeutic choices and long-term health outcomes for CHB patients.

Purpose of the Study:

  • To investigate patient preferences regarding CHB treatment.
  • To identify key factors influencing patient selection of CHB therapies.

Main Methods:

  • Questionnaire-based survey of CHB patients at a follow-up clinic.
  • Assessed knowledge, preferred administration route/frequency, duration, cost, adverse events, resistance, efficacy, and doctor discussions.
  • Patients ranked priorities and selected preferred therapy after reviewing drug profiles.

Main Results:

  • Lamivudine was the most recognized drug; entecavir was the preferred therapy.
  • Most patients favored oral, once-daily dosing with a fixed treatment duration.
  • Drug efficacy was the primary selection factor; patients expected cure and were willing to pay up to $10 daily.

Conclusions:

  • Patient preferences are crucial for evaluating and selecting CHB treatments.
  • Aligning treatment choices with patient preferences can improve adherence and outcomes.