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Venous thrombotic events in hospitalized children and adolescents with inflammatory bowel disease

Cade M Nylund1, Anthony Goudie, Jose M Garza

  • 1Department of Pediatrics, Uniformed Services University of Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA. cade.nylund@usuhs.mil

Journal of Pediatric Gastroenterology and Nutrition
|December 13, 2012
PubMed

Insights

Children and adolescents with inflammatory bowel disease (IBD) face a higher risk of venous thrombotic events (TEs). Early prevention strategies are crucial for hospitalized pediatric IBD patients.

Area of Science:

  • Pediatric Gastroenterology
  • Hematology
  • Public Health

Background:

  • Adults with inflammatory bowel disease (IBD) exhibit an elevated risk of venous thrombotic events (TEs).
  • Limited data exists on the risk of TEs in pediatric populations with IBD.

Purpose of the Study:

  • To assess the risk of TEs in hospitalized children and adolescents diagnosed with IBD.
  • To identify risk factors associated with TE development in pediatric IBD patients.

Main Methods:

  • Retrospective cohort study utilizing the Healthcare Cost and Utilization Project Kids' Inpatient Database (1997-2009).
  • Billing codes identified pediatric patients with IBD and various thrombotic events.
  • Logistic regression analysis was employed to determine the adjusted odds ratio for TE in IBD patients.

Main Results:

  • The incidence of any TE in hospitalized children with IBD was 117.9 per 10,000, with a relative risk of 2.36.
  • Adjusted odds ratio for TE in non-surgical IBD patients was 1.22.
  • Identified risk factors for TE in pediatric IBD patients included older age, central venous catheter use, parenteral nutrition, and hypercoagulable conditions.

Conclusions:

  • Hospitalized pediatric patients with IBD are at a significantly increased risk for developing TEs.
  • Conservative preventative measures such as hydration, mobilization, and pneumatic devices should be considered for hospitalized IBD patients.
Abstract

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