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Updated: May 16, 2026

Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia
Published on: December 28, 2014
Leukoaraiosis and sex predict the hyperacute ischemic core volume
Nils Henninger1, Eugene Lin, Diogo C Haussen
1Department of Neurology, University of Massachusetts Medical School, 55 Lake Ave, N Worcester, MA 01655, USA. nils.henninger@umassmed.edu
Severe leukoaraiosis (LA) and male sex are linked to larger acute stroke infarct cores. Women showed smaller core volumes, suggesting sex and LA impact brain susceptibility to ischemia.
Area of Science:
- Neurology
- Stroke Medicine
- Neuroimaging
Background:
- Leukoaraiosis (LA) and male sex are linked to reduced cerebrovascular reactivity.
- This may negatively impact tissue viability in acute stroke patients.
Purpose of the Study:
- To determine the impact of LA severity and sex on acute ischemic core volume.
- Investigate predictors of hyperacute infarct volume in intracranial large artery occlusion.
Main Methods:
- Analysis of multimodal CT imaging in 87 acute stroke patients.
- LA severity assessed using the van Swieten scale; CT perfusion analyzed for infarct core volume.
- Multivariate regression identified independent predictors of infarct volume.
Main Results:
- Severe LA (van Swieten Scale 3-4) and male sex independently predicted larger infarct cores (>25 mL).
- Severe LA and male sex were associated with larger cerebral blood volume lesions.
- Women had significantly smaller cerebral blood volume lesion volumes than men.
Conclusions:
- Severe LA and male sex are associated with larger infarct cores in acute stroke.
- Sex and LA severity influence the brain's susceptibility to acute ischemia.
- Further research is needed to confirm smaller core volumes in women and their implications.
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