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Related Experiment Videos

Interaction between halothane and morphine on isolated heart muscle.

M L Laorden1, J Hernandez, M D Carceles

  • 1Department of Physiology and Pharmacology, School of Medicine, Murcia, Spain.

European Journal of Pharmacology
|January 17, 1990
PubMed
Summary

Halothane enhances morphine

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Area of Science:

  • Pharmacology
  • Anesthesiology
  • Cardiovascular Physiology

Background:

  • Morphine, an opiate agonist, exhibits negative inotropic effects on cardiac muscle.
  • The interaction between anesthetics and opioid analgesics requires further elucidation.

Purpose of the Study:

  • To investigate the influence of halothane on the negative inotropic activity of morphine.
  • To determine the role of opioid receptors in mediating halothane's effect on morphine.

Main Methods:

  • Isolated rat left atria were used to assess contractile force.
  • Concentration-response curves for morphine were generated.
  • The effects of halothane and naloxone isomers (L- and D-naloxone) were evaluated.

Main Results:

  • Morphine significantly reduced contractile force in rat left atria.
  • Halothane (1.5% v/v) significantly increased morphine's potency (decreased IC16).
  • L-naloxone, but not D-naloxone, antagonized the inhibitory effects of morphine in the presence of halothane.

Conclusions:

  • Halothane potentiates the negative inotropic effects of morphine on isolated rat atria.
  • The observed potentiation is likely mediated through opioid receptors.

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