Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Insights into Clinical Challenges and Management of Primary and Secondary Antibody Deficiency in Pregnancy.

The journal of allergy and clinical immunology. In practice·2026
Same author

Automated data extraction model for the USIDNET registry: Bigger, faster, and better data collection.

Journal of human immunity·2026
Same author

A systematic literature review of CVID reveals pervasive detrimental noninfectious manifestations.

Journal of human immunity·2026
Same author

IgD from atypical-like memory B cells and plasma cells targets commensal and environmental antigens.

The Journal of experimental medicine·2026
Same author

Homozygosity for rare or common hypomorphic <i>IL23R</i> variants confers a predisposition to tuberculosis in humans.

bioRxiv : the preprint server for biology·2026
Same author

Heterozygous NFKB1 variant causes inflammatory dysregulation shaped by broader genetic context in common variable immunodeficiency.

JCI insight·2026

Related Experiment Video

Updated: May 16, 2026

Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens
06:03

Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens

Published on: September 20, 2024

The many faces of common variable immunodeficiency.

Charlotte Cunningham-Rundles1

  • 1Immunology Institute and the Departments of Medicine and Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA.

Hematology. American Society of Hematology. Education Program
|December 13, 2012
PubMed
Summary
This summary is machine-generated.

Common variable immunodeficiency (CVID) is a rare disorder affecting antibody production. Identifying distinct CVID phenotypes aids in understanding disease complexity and predicting patient outcomes.

More Related Videos

Development of an IFN-&#947; ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR
14:14

Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR

Published on: December 6, 2014

Related Experiment Videos

Last Updated: May 16, 2026

Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens
06:03

Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens

Published on: September 20, 2024

Development of an IFN-&#947; ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR
14:14

Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR

Published on: December 6, 2014

Area of Science:

  • Immunology
  • Clinical Medicine
  • Genetics

Background:

  • Common variable immunodeficiency (CVID) is a heterogeneous immune disorder marked by reduced immunoglobulin levels and impaired antibody production.
  • CVID diagnosis typically occurs in adults aged 20-40, but can affect individuals across all age groups.
  • Clinical presentations are diverse, encompassing recurrent infections, autoimmune conditions, and increased cancer risk.

Purpose of the Study:

  • To review current understanding of CVID based on large patient cohort data.
  • To highlight the identification of distinct CVID phenotypes.
  • To emphasize the evaluation and management of CVID-associated complications, particularly autoimmune and inflammatory issues.

Main Methods:

  • Analysis of data from large patient registries.
  • Clinical phenotyping and laboratory marker assessment.
  • Review of existing literature on CVID cohorts.

Main Results:

  • CVID can be categorized into two main phenotypes: infection-predominant and those with significant inflammatory/hematologic complications.
  • These phenotypes are stable, correlate with immunologic markers, and predict patient outcomes.
  • Patient registries provide valuable insights into disease heterogeneity and biologically relevant subgroups.

Conclusions:

  • Phenotypic classification of CVID offers a framework for understanding disease complexity and guiding treatment.
  • Early identification and management of autoimmune and inflammatory complications are crucial for improving CVID patient outcomes.
  • Continued research using large cohorts is essential for advancing CVID diagnosis and therapeutic strategies.