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Updated: May 16, 2026
04:40
Venous Thrombosis Assay in a Mouse Model of Cancer
Published on: January 5, 2024
Cancer-associated thrombosis: updates and controversies.
1James P. Wilmot Cancer Center and Department of Medicine, University of Rochester, Rochester, NY, USA. alok_khorana@urmc.rochester.edu
Hematology. American Society of Hematology. Education Program
|December 13, 2012
Summary
Recent findings improve understanding of cancer-associated thrombosis. Incidental venous thromboembolism (VTE) and new risk assessments show outpatient prophylaxis is effective, though patient selection remains debated.
Area of Science:
- Oncology
- Hematology
- Vascular Medicine
Background:
- Cancer-associated thrombosis is a significant cause of morbidity and mortality.
- Understanding of cancer-associated thrombosis has been limited.
Purpose of the Study:
- To review recent advancements in understanding and managing cancer-associated thrombosis.
- To highlight new findings on incidental venous thromboembolism (VTE), risk assessment, and prophylaxis in cancer patients.
Main Methods:
- Review of emerging data on cancer-associated thrombosis.
- Analysis of findings from randomized clinical trials on prophylaxis in cancer outpatients.
- Evaluation of novel risk assessment approaches and biomarkers.
Main Results:
- Incidental VTE contributes significantly to cancer-associated VTE and has similar outcomes to symptomatic VTE.
- Elevated platelet counts, leukocyte counts, and low hemoglobin are key biomarkers.
- A validated risk score for chemotherapy-associated VTE is ready for clinical use.
- Outpatient thromboprophylaxis with low-molecular-weight heparins is feasible, safe, and effective for solid-tumor patients.
Conclusions:
- Recent data enhance understanding of cancer-associated thrombosis, including incidental VTE.
- Novel risk assessment tools and biomarkers are available for clinical use.
- Outpatient thromboprophylaxis is effective, but patient selection requires further consideration.
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