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On the evolutionary history of the circumsporozoite protein in plasmodia
L di Giovanni1, A H Cochrane, V Enea
1Department of Medical and Molecular Parasitology, New York University Medical Center, New York 10010.
Experimental Parasitology
|May 1, 1990
Abstract:
We report the complete nucleotide sequence of the circumsporozoite (CS) gene of Plasmodium brasilianum and present an analysis of its evolutionary profile. Despite the lack of a reliable time scale, the analysis of the number and distribution of fixations among seven taxa provides a first glimpse of the evolutionary history of the CS gene, and suggests that the branching events of this gene are completely unconnected with--and far precede in time--the speciation event of the parasite's vertebrate hosts.