Related Experiment Video
Updated: May 16, 2026
12:18
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
Caloric intake, aging, and mild cognitive impairment: a population-based study.
Yonas E Geda1, Marion Ragossnig, Lewis A Roberts
1Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. geda.yonas@mayo.edu
Journal of Alzheimer'S Disease : JAD
|December 14, 2012
Summary
High caloric intake nearly doubles the odds of developing mild cognitive impairment (MCI). Moderate caloric intake showed no significant association with MCI risk in older adults.
Area of Science:
- Neurology
- Nutritional Science
- Epidemiology
Background:
- Mild cognitive impairment (MCI) is a precursor to dementia.
- Dietary factors, including caloric intake, are being investigated for their role in cognitive health.
- Understanding the relationship between caloric consumption and MCI is crucial for public health strategies.
Purpose of the Study:
- To investigate the association between different levels of caloric intake and the odds of having mild cognitive impairment (MCI).
- To determine if moderate and high caloric intakes have differential effects on MCI risk.
Main Methods:
- Population-based case-control study using data from the Mayo Clinic Study of Aging.
- Included 1,072 cognitively normal individuals and 161 subjects with MCI, aged 70-92 years.
- Caloric intake assessed via Food Frequency Questionnaire; multivariable logistic regression used for analysis, adjusting for covariates.
Main Results:
- High caloric intake (>2,143 kcals/day) was significantly associated with nearly double the odds of MCI (OR 1.96, 95% CI 1.26-3.06).
- Moderate caloric intake (1,526 to 2,143 kcals/day) was not significantly associated with MCI odds compared to the reference group (OR 0.87, 95% CI 0.53-1.42).
- Stratified analyses by apolipoprotein E ε4 genotype status were also conducted.
Conclusions:
- High caloric intake is associated with an increased likelihood of mild cognitive impairment in older adults.
- Moderate caloric intake does not appear to increase MCI risk.
- Further research is needed to establish a causal relationship.
Related Concept Videos
01:30Cognitive Development During Adulthood
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
01:26Aging
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
01:19The Effect of Aging on Tissues
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
01:29Alzheimer Disease l: Introduction
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
01:37Mitochondria
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...