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Updated: May 16, 2026
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
[Multidisciplinary treatment for gastric cancer with peritoneal metastasis]
Hironori Ishigami1, Joji Kitayama, Hironori Yamaguchi
1Dept. of Outpatient Chemotherapy, The University of Tokyo, Japan.
Abstract:
The standard of care for gastric cancer with peritoneal metastasis is systemic chemotherapy. However, there is no chemotherapy regimen with a sufficient level of evidence supporting its effectiveness, and thus S-1 plus cisplatin(CDDP), which is regarded as the standard regimen for advanced metastatic gastric cancer, is widely applied. Meanwhile, the efficacy of intraperitoneal(IP)administration of taxanes has been verified, and the novel multidisciplinary treatment combining chemotherapy and surgery is now being tested. We developed a combination chemotherapy regimen of S -1, weekly intravenous and IP paclitaxel(PTX), and determined the recommended dose of IP PTX to be 20mg/m2 in our phase I study. In our phase II study, the median survival time(MST)of 40 patients enrolled was 23. 6 months, and peritoneal cytology turned negative for 86% of 28 patients. Moreover, we performed gastrectomy on 60 patients after the disappearance or obvious shrinkage of peritoneal metastasis, and the MST was 34. 5 months. Multidisciplinary treatment combining IP-containing chemotherapy and surgery is safe and effective for gastric cancer patients with peritoneal metastasis. We have started a phase III trial(PHOENIX-GC trial)comparing our IP regimen to S-1 plus CDDP.
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