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Altered fibrin clot properties in patients with premature peripheral artery disease

Agnieszka Okraska-Bylica1, Tadeusz Wilkosz, Lidia Słowik

  • 1Department of Diagnostics, John Paul II Hospital, Kraków, Poland. aokraska@szpitaljp2.krakow.pl

Polskie Archiwum Medycyny Wewnetrznej
|December 14, 2012
PubMed

Insights

Peripheral artery disease (PAD) patients, both premature and older, exhibit abnormal fibrin clot formation. Premature PAD independently predicts clot permeability and absorbance, highlighting its thrombotic risk.

Area of Science:

  • Vascular Biology
  • Thrombosis Research
  • Clinical Medicine

Background:

  • Elderly patients with peripheral artery disease (PAD) often display denser, poorly lysable fibrin clots.
  • This study investigates whether premature PAD is linked to a more prothrombotic fibrin clot phenotype.

Purpose of the Study:

  • To test the hypothesis that premature PAD is associated with a more prothrombotic fibrin clot phenotype.
  • To compare fibrin clot characteristics between premature PAD, older PAD patients, and controls.

Main Methods:

  • Ex-vivo analysis of plasma fibrin clot permeability, turbidity, and lysis time.
  • Study included 31 premature PAD patients (age ≤55), 32 older PAD patients (age >55), and 40 age/sex-matched controls.
  • Ankle-brachial index (ABI) was used to assess PAD severity.

Main Results:

  • Premature PAD patients showed significantly lower clot permeability (Ks), longer clot lysis time (t50%), and higher maximum D-dimer levels (D-Dmax) compared to controls.
  • These differences persisted after adjusting for risk factors and medications.
  • No significant differences in fibrin clot parameters were observed between premature and older PAD patients.

Conclusions:

  • Plasma fibrin clots exhibit a similarly abnormal prothrombotic phenotype in both premature and older PAD patients.
  • Factors influencing fibrin clot parameters differ between premature and older PAD groups.
  • Premature PAD was identified as an independent predictor of clot permeability and maximum fibrin gel absorbance.
Abstract

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