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Related Experiment Video

Updated: May 16, 2026

Surgical Treatment for Benign Prostatic Hyperplasia: Holmium Laser Enucleation of the Prostate (HoLEP).
06:04

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Published on: March 6, 2018

Serenoa repens for benign prostatic hyperplasia.

James Tacklind1, Roderick Macdonald, Indy Rutks

  • 1Center for Chronic Disease Outcomes Research (111-0), Minneapolis Veterans Affairs Medical Center, Minneapolis, MN, USA. james.tacklind@va.gov

The Cochrane Database of Systematic Reviews
|December 14, 2012
PubMed
Summary
This summary is machine-generated.

Serenoa repens (SR) did not show superiority over placebo in improving lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). This systematic review found no significant benefits in urinary flow, prostate size, or nocturia for men treated with SR.

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Area of Science:

  • Urology
  • Pharmacology
  • Integrative Medicine

Background:

  • Benign prostatic hyperplasia (BPH) is a common condition causing lower urinary tract symptoms (LUTS) in men.
  • Phytotherapy, particularly using Serenoa repens (SR), is a popular treatment approach for BPH-related LUTS.
  • SR, derived from the American saw palmetto plant, is widely available for managing BPH symptoms.

Purpose of the Study:

  • To systematically review the efficacy and safety of Serenoa repens (SR) for treating LUTS in men with BPH.
  • To assess the impact of SR on urologic symptom scales, nocturia, and urodynamic measurements.
  • To evaluate the harms and side effects associated with SR use in this patient population.

Main Methods:

  • A comprehensive search of multiple databases and clinical trial registries was conducted.
  • Eligibility criteria included randomized controlled trials comparing SR preparations with placebo or other interventions for at least four weeks.
  • Data extraction and analysis focused on changes in urologic symptom scores, nocturia, urodynamic measures, and reported side effects.

Main Results:

  • Meta-analysis of high-quality trials (n=582) showed SR was not superior to placebo in reducing LUTS (MD 0.25 points, 95% CI -0.58 to 1.07).
  • A 72-week trial found SR did not improve symptom scores, clinical responder rates, or nocturia compared to placebo.
  • SR did not significantly improve peak urine flow or reduce prostate size compared to placebo in high-quality trials.

Conclusions:

  • Serenoa repens, even at double and triple doses, demonstrated no significant improvement in urinary flow measures or prostate size for men with BPH-related LUTS.
  • The findings suggest that SR is not more effective than placebo for the studied outcomes in men with symptomatic BPH.
  • This systematic review did not alter previous conclusions regarding the efficacy of SR for BPH.