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Updated: May 16, 2026

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
06:45

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Published on: February 10, 2023

Pentoxifylline for treating venous leg ulcers.

Andrew B Jull1, Bruce Arroll, Varsha Parag

  • 1School of Nursing, University of Auckland, Auckland, New Zealand. a.jull@auckland.ac.nz.

The Cochrane Database of Systematic Reviews
|December 14, 2012
PubMed
Summary

Pentoxifylline improves venous leg ulcer healing, with or without compression therapy. This drug enhances healing compared to placebo but may cause gastrointestinal side effects.

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Last Updated: May 16, 2026

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
06:45

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Published on: February 10, 2023

Area of Science:

  • Vascular Medicine
  • Dermatology
  • Wound Healing

Background:

  • Compression bandaging is standard for venous leg ulcers, but some ulcers resist treatment or patients cannot tolerate compression.
  • Pentoxifylline, a hemorheologic agent improving blood flow, has been explored for venous leg ulcer treatment.

Purpose of the Study:

  • To evaluate the efficacy of pentoxifylline in treating venous leg ulcers.
  • To compare pentoxifylline with placebo or other therapies, with or without compression.

Main Methods:

  • Systematic review and meta-analysis of randomized controlled trials.
  • Searched multiple databases including Cochrane, MEDLINE, EMBASE, and CINAHL up to July 2012.
  • Included 12 trials with 864 participants, assessing healing rates and adverse effects.

Main Results:

  • Pentoxifylline significantly improved complete ulcer healing or significant improvement compared to placebo (RR 1.70).
  • Combined pentoxifylline and compression therapy showed greater effectiveness than placebo plus compression (RR 1.56).
  • Pentoxifylline alone was more effective than placebo or no treatment (RR 2.25), though adverse effects, primarily gastrointestinal, were more frequent (RR 1.56).

Conclusions:

  • Pentoxifylline is an effective addition to compression bandaging for venous leg ulcers.
  • Pentoxifylline may also be beneficial for venous leg ulcers when compression therapy is not feasible.
  • Gastrointestinal disturbances were the most common adverse events associated with pentoxifylline use.