Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thrombectomy in Posterior Circulation Tandem Occlusions: Multicenter Comparative Analysis of Procedural Techniques and Predictors of Clinical Outcomes.

Radiologyยท2026
Same author

Woven Endobridge device for ruptured vs. unruptured aneurysms: insights from the WorldWideWEB study.

Neuroradiologyยท2026
Same author

Endovascular thrombectomy for patients with large-core ischaemic stroke presenting up to 24 h after onset (ATLAS): a systematic review and individual patient data meta-analysis with central imaging adjudication.

Lancet (London, England)ยท2026
Same author

Single-layer spherical (SLS) vs single-layer (SL) Woven EndoBridge (WEB) device in the treatment of narrow-neck intracranial aneurysms: a propensity score-matched analysis.

Neurosurgical reviewยท2026
Same author

Large and giant intracranial aneurysms: outcomes from the multicenter prospective SMART coils registry.

Frontiers in neurologyยท2026
Same author

Cross-Sectional Imaging Modalities in Correlation to the Thrombolysis in Cerebral Infarction Score: The Next Frontier in Adjunctive Endovascular Stroke Therapy.

Stroke (Hoboken, N.J.)ยท2026

Related Experiment Video

Updated: May 16, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Assessing variability in neurointerventional practice patterns for acute ischemic stroke.

Brijesh Mehta1, Thabele M Leslie-Mazwi, Ronil V Chandra

  • 1Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA. bmehta@partners.org

Journal of Neurointerventional Surgery
|December 14, 2012
PubMed
Summary

Intra-arterial therapy (IAT) for acute stroke shows wide practice variations globally. This study reveals a need for standardized, evidence-based guidelines to optimize treatment for large vessel occlusions.

More Related Videos

Simulator Training for Endovascular Neurosurgery
08:08

Simulator Training for Endovascular Neurosurgery

Published on: May 6, 2020

Related Experiment Videos

Last Updated: May 16, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Simulator Training for Endovascular Neurosurgery
08:08

Simulator Training for Endovascular Neurosurgery

Published on: May 6, 2020

Area of Science:

  • Neurointerventional medicine
  • Acute stroke management
  • Vascular neurology

Background:

  • Intra-arterial therapy (IAT) is a growing treatment for acute stroke with large vessel occlusions.
  • Limited data and guidelines exist for IAT indications and standards.
  • Understanding real-world practice patterns is crucial for improving patient care.

Purpose of the Study:

  • To investigate current practice patterns for intra-arterial therapy (IAT) in acute stroke.
  • To identify variations in treatment indications, protocols, and decision-making processes.
  • To highlight areas where evidence-based guidelines are needed.

Main Methods:

  • An international internet-based survey was distributed to neurointerventionalists.
  • The survey covered practice setting, operator background, protocols, quality, safety, decision-making, and treatment strategies.
  • Data from 140 respondents were analyzed.

Main Results:

  • Significant variability exists in IAT case volumes, institutional resources, and operator experience.
  • Treatment decisions often rely on clinical and imaging findings rather than strict time windows or NIH Stroke Scale cut-offs.
  • Diverse imaging criteria and mechanical device preferences were reported, with high rates of IAT following intravenous thrombolysis.

Conclusions:

  • Real-world application of intra-arterial therapy for acute stroke demonstrates considerable heterogeneity among practitioners.
  • The findings underscore an urgent need for the development and implementation of evidence-based practice guidelines.
  • Standardization of IAT protocols could improve consistency and outcomes in stroke treatment.