Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Esophageal Achalasia01:27

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Gastroesophageal Reflux Disease01:25

Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alcohol exposure induces ferroptosis-dominated programmed cell death in esophageal epithelial cells.

BMC molecular and cell biology·2026
Same author

CCN1 promotes APRIL/BAFF signaling in esophageal squamous cell carcinoma but attenuates it in esophageal adenocarcinoma.

Scientific reports·2025
Same author

Cellular communication network 1 promotes CASP2 mRNA expression but suppresses its protein translation in esophageal adenocarcinoma.

Journal of cell communication and signaling·2024
Same author

Baseline Features and Reasons for Nonparticipation in the Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) Study, a Colorectal Cancer Screening Trial.

JAMA network open·2023
Same author

The Application of Probe-Based Confocal Laser Endomicroscopy as a Diagnostic Tool in Choledochoscopic Gallbladder-Preserving Surgery.

Digestive diseases (Basel, Switzerland)·2022
Same author

Esophageal Achalasia: From Laparoscopic to Robotic Heller Myotomy and Dor Fundoplication.

JSLS : Journal of the Society of Laparoendoscopic Surgeons·2022
Same journal

Lessons from extended induction and practical evidence for improving tofacitinib therapy in ulcerative colitis.

World journal of gastroenterology·2026
Same journal

Small animal <i>ex vivo</i> machine perfusion of the liver: A comprehensive literature review.

World journal of gastroenterology·2026
Same journal

Comparable remission and health care use in real-world inflammatory bowel disease patients initiating originator biologics <i>vs</i> biosimilars.

World journal of gastroenterology·2026
Same journal

Diagnosis and management of metabolic dysfunction-associated steatohepatitis in patients with chronic hepatitis B infection.

World journal of gastroenterology·2026
Same journal

Simultaneous treatment of concomitant achalasia coexisting with epiphrenic diverticulum: The practice of submucosal tunneling technique.

World journal of gastroenterology·2026
Same journal

Lianhe Xiaozhi ointment ameliorates metabolic dysfunction-associated steatotic liver disease <i>via</i> peroxisome proliferator-activated receptor alpha pathway activation.

World journal of gastroenterology·2026
See all related articles

Related Experiment Video

Updated: May 16, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Esophageal malignancy: a growing concern.

Jianyuan Chai, M Mazen Jamal

    World Journal of Gastroenterology
    |December 14, 2012
    PubMed
    Summary
    This summary is machine-generated.

    Esophageal cancer, especially adenocarcinoma, is rapidly increasing in the US, linked to obesity and GERD. Current treatments are insufficient, necessitating urgent research into new therapeutic options for this deadly disease.

    Keywords:
    Esophageal cancerGastroesophageal reflux diseaseObesity

    More Related Videos

    Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
    10:43

    Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

    Published on: December 23, 2022

    Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
    10:42

    Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

    Published on: July 6, 2022

    Related Experiment Videos

    Last Updated: May 16, 2026

    Development of Compendium for Esophageal Squamous Cell Carcinoma
    03:36

    Development of Compendium for Esophageal Squamous Cell Carcinoma

    Published on: April 12, 2024

    Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
    10:43

    Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

    Published on: December 23, 2022

    Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
    10:42

    Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

    Published on: July 6, 2022

    Area of Science:

    • Oncology
    • Gastroenterology
    • Epidemiology

    Background:

    • Esophageal cancer, historically prevalent in Asia and East Africa, is increasingly recognized in Western nations.
    • Esophageal adenocarcinoma incidence has surged sixfold annually in the US, becoming the fastest-growing cancer.
    • Obesity-driven gastroesophageal reflux disease (GERD) is a primary risk factor, progressing from esophagitis to adenocarcinoma.

    Discussion:

    • Acid suppression therapy, the standard for GERD, shows limited efficacy against esophageal malignancy and carries significant side effects.
    • The rising incidence and high mortality of esophageal cancer underscore the inadequacy of current management strategies.
    • Regulatory agencies have issued warnings regarding the adverse effects of acid suppression medications.

    Key Insights:

    • A strong correlation exists between rising obesity rates, increased GERD prevalence, and the escalating incidence of esophageal adenocarcinoma.
    • Long-term GERD is a critical precursor to esophageal adenocarcinoma, highlighting the need for effective GERD management.
    • Existing treatments for GERD do not adequately address the oncogenic potential of the condition.

    Outlook:

    • Further research into the molecular mechanisms driving esophageal cancer development is crucial.
    • Development of novel therapeutic strategies targeting esophageal adenocarcinoma is urgently needed.
    • Investigating alternative or adjunct treatments for GERD that mitigate cancer risk is a priority.