Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Antibiotic Selection00:57

Antibiotic Selection

Overview
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From antimicrobial-impregnated to standard catheters for external ventricular drainage: a single-center before-and-after cohort study.

Acta neurochirurgica·2026
Same author

Dissemination of ESBL-producing <i>Escherichia coli</i> and carriage in the community worldwide: epidemiology, transmission pathways, molecular insights, and practical aspects.

Clinical microbiology reviews·2026
Same author

Effects of septic shock vasopressors on the fitness of Escherichia coli.

Scientific reports·2026
Same author

Piperacillin-tazobactam resistance in <i>Klebsiella pneumoniae</i> is often associated with IS<i>26-</i>mediated <i>bla</i><sub>SHV-1</sub> amplification in a widespread <i>Klebsiella</i>-adapted plasmid.

Antimicrobial agents and chemotherapy·2026
Same author

The antimicrobial gut resistome of the Wayampi reveals a shared background of antibiotic and metal resistance genes with industrialized populations, underscoring the "robust-yet-fragile" architecture of human gut microbiomes.

Microbiome·2026
Same author

Real-life impact of clinical metagenomics in the intensive care unit: a multicenter retrospective study in greater paris area hospitals.

Critical care (London, England)·2026

Related Experiment Video

Updated: May 16, 2026

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
09:00

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance

Published on: May 2, 2018

[How to explain antibiotic resistance?].

Paul-Louis Woerther1, Antoine Andremont

  • 1Laboratoire de microbiologie, institut Gustave-Roussy, CLCC, 94800 Villejuif, France. paul-louis.woerther@igr.fr

La Revue Du Praticien
|December 15, 2012
PubMed
Summary
This summary is machine-generated.

Antibiotic resistance is a growing global problem in healthcare, leading to untreatable infections. This synthesis explores the rapid emergence and spread of drug-resistant bacteria due to antibiotic use.

More Related Videos

Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing
08:19

Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing

Published on: July 7, 2020

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

Related Experiment Videos

Last Updated: May 16, 2026

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
09:00

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance

Published on: May 2, 2018

Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing
08:19

Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing

Published on: July 7, 2020

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

Area of Science:

  • Microbiology
  • Public Health
  • Infectious Diseases

Context:

  • Antibiotic resistance poses a significant global health threat, impacting both community and hospital settings.
  • The increasing prevalence of resistant bacteria creates challenging therapeutic scenarios, often referred to as 'treatment dead ends'.

Purpose:

  • To elucidate the underlying factors contributing to the rapid emergence and widespread dissemination of antibiotic-resistant bacteria.
  • To analyze the mechanisms driving bacterial resistance after a relatively short period of antibiotic application.

Summary:

  • The widespread use of antibiotics has accelerated the evolution and spread of bacteria that are difficult or impossible to treat with current medications.
  • This phenomenon presents a critical challenge to modern medicine, necessitating a deeper understanding of resistance development.

Impact:

  • Highlights the urgent need for strategies to combat antibiotic resistance and preserve the efficacy of existing treatments.
  • Informs public health policies and clinical practices aimed at mitigating the impact of untreatable bacterial infections.