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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

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The rise of developmental genetics - a historical account of the fusion of embryology and cell biology with human genetics and the emergence of the Stem Cell Initiative.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2016
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TYPES OF ALBINISM IN THE BLACK SOUTHERN AFRICA POPULATION.

East African medical journal·2016
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A new class of stem cells in South Africa: iPS cells.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2012
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Advances in imaging the blood and aqueous vessels of the ocular limbus.

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A rare repigmentation pattern in a vitiligo patient: a clue to an epidermal stem-cell reservoir of melanocytes?

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Related Experiment Video

Updated: May 16, 2026

Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)
20:38

Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)

Published on: February 25, 2007

Stem cell transplantation: a collegial conversation.

S H Kidson, G Jordaan

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |December 15, 2012
    PubMed
    Summary

    Stem cell transplant procedures are under scrutiny. Experts weigh in on the methodology for producing stem cells, sparking ongoing scientific debate regarding safety and efficacy in neurosurgery.

    Area of Science:

    • Neurosurgery
    • Stem Cell Science

    Background:

    • A recent neurosurgical case involving a stem cell transplant has raised concerns.
    • The South African Medical Journal (SAMJ) is exploring these concerns to inform readers.

    Purpose of the Study:

    • To provide expert opinions on the methodology of stem cell production for transplantation.
    • To facilitate understanding of a specific stem cell transplant case.

    Main Methods:

    • Consultation with Professor Susan Kidson, a leading stem cell scientist, for insights into stem cell production.
    • Inclusion of Dr. Gert Jordaan's explanation of his stem cell cultivation methodology, translated from Afrikaans.

    Main Results:

    • Professor Kidson provided an analysis of the stepwise production of suitable stem cells.

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    In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
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    Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)
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    Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)

    Published on: February 25, 2007

    Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice
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    05:32

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    Published on: February 16, 2024

  • Dr. Jordaan detailed his methodology for raising stem cells used in the transplant.

    • Conclusions:

    • The presented information is intended to aid reader comprehension of the stem cell transplant case.
    • The debate surrounding the neurosurgical stem cell procedure is expected to continue.