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Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

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Published on: March 4, 2014

Jamar hand-held grip dynamometry in chronic inflammatory demyelinating polyneuropathy.

Yusuf A Rajabally¹, Manisha Narasimhan

¹Neuromuscular Clinic, Departments of Neurology and Neurophysiology, University Hospitals of Leicester, Leicester, UK. yusuf.rajabally@uhl-tr.nhs.uk

Journal of the Neurological Sciences

|December 15, 2012

Summary

Grip dynamometry accurately measures overall neurological function in chronic inflammatory demyelinating polyneuropathy (CIDP). For treated CIDP patients, achieving fifth percentile grip strength may be a realistic functional goal.

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Area of Science:

Neurology
Clinical Electrophysiology

Background:

Limited research exists on grip dynamometry's functional and electrophysiological links in neuromuscular disorders.
The clinical utility of normative grip strength values in these conditions is unclear.

Purpose of the Study:

To evaluate the clinical and electrophysiological correlates of hand-held grip dynamometry in chronic inflammatory demyelinating polyneuropathy (CIDP).
To assess the utility of normative grip strength values in CIDP patients.

Main Methods:

A cross-sectional study involving 31 prospectively recruited CIDP patients.
Utilized Jamar hand-held grip dynamometry, standard clinical assessments, and electrophysiology.

Main Results:

Grip dynamometry showed strong correlations with upper limb motor, sensory, and functional scores, as well as global function.
Significant correlations were found with median/ulnar and ulnar compound muscle action potentials.
CIDP patients' grip strength was lower than median norms but aligned with fifth percentile values.

Conclusions:

Jamar grip dynamometry reliably reflects global neurological status in CIDP, extending beyond upper limb or motor function.
Fifth percentile normative values may serve as a practical target for optimal function in treated CIDP patients.