Related Experiment Video

Updated: May 16, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
08:43

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

[Collateral blood flow in the myocardium: the role of endothelial growth factor]

I V Starostin, K A Talitskiĭ, O S Bulkina

    Kardiologiia
    |December 15, 2012
    PubMed

    Insights

    Collateral blood flow in ischemic heart disease varies greatly. Understanding factors like vascular endothelial growth factor-A (VEGF-A) and its genetic variations can improve treatment and patient outcomes.

    Area of Science:

    • Cardiovascular Physiology
    • Molecular Biology
    • Genetics

    Context:

    • Collateral blood flow is a critical compensatory mechanism in myocardial ischemia.
    • Its efficacy is highly variable among individuals, impacting patient prognosis.
    • Identifying modifiable factors influencing collateral circulation is key to improving outcomes.

    Purpose:

    • To review the significance of collateral blood flow in ischemic heart disease.
    • To analyze the mechanisms underlying collateral formation.
    • To highlight the role of vascular endothelial growth factor-A (VEGF-A) and its genetic polymorphism.

    Summary:

    • Collateral blood flow, a natural compensation for reduced blood supply in ischemic myocardium, exhibits significant individual variability.
    • This review examines the importance of collateral circulation, its formation mechanisms, and emphasizes the role of vascular endothelial growth factor-A (VEGF-A) and its genetic variations.
    • Understanding these factors is crucial for developing strategies to enhance collateral function.

    Impact:

    • Improving the understanding of collateral blood flow can lead to targeted therapies for ischemic heart disease.
    • Identifying modifiable factors may enhance the efficacy of collateral circulation, improving patient quality of life.
    • Focusing on VEGF-A and its genetic polymorphism offers potential avenues for personalized treatment strategies.

    More Related Videos

    In Vitro Model of Coronary Angiogenesis08:03

    In Vitro Model of Coronary Angiogenesis

    Published on: March 10, 2020

    Related Concept Videos

    Regulation of Angiogenesis and Blood Supply01:24

    Regulation of Angiogenesis and Blood Supply

    Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
    Mechanism of Angiogenesis01:10

    Mechanism of Angiogenesis

    Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
    Role of Hematopoietic Growth Factors01:28

    Role of Hematopoietic Growth Factors

    Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
    Thrombopoietin (TPO), mainly released by the liver,...