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[Lercanidipine in the treatment of arterial hypertension]

L O Minushkina, I K Iosava

    Kardiologiia
    |December 15, 2012
    PubMed

    Insights

    Lercanidipine, a third-generation dihydropyridine calcium antagonist, effectively treats hypertension with long-lasting effects and organ-protective benefits. Its good tolerability and minimal sympathetic activation lead to high patient adherence.

    Area of Science:

    • Pharmacology
    • Cardiovascular Medicine

    Context:

    • Hypertension management
    • Third-generation dihydropyridine calcium antagonists

    Purpose:

    • To review the effectiveness and properties of lercanidipine.
    • To highlight its organ-protective effects and tolerability.

    Summary:

    • Lercanidipine exhibits high vasoselectivity and a long duration of action, providing a good antihypertensive effect.
    • It is suitable for elderly patients with isolated hypertension, offering nephroprotection and reducing left ventricular hypertrophy.
    • The drug improves vascular elasticity and reduces central pressure with minimal sympathetic activation, ensuring good tolerability and adherence.

    Impact:

    • Lercanidipine offers a well-tolerated and effective treatment option for hypertension, particularly in elderly patients.
    • Its organ-protective properties contribute to improved cardiovascular health and patient outcomes.
    • High adherence rates suggest a favorable patient experience with lercanidipine therapy.

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