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Uric acid increases the incidence of ventricular arrhythmia in patients with left ventricular hypertrophy

Shinya Yamada1, Hitoshi Suzuki, Masashi Kamioka

  • 1Department of Cardiology and Hematology, Fukushima Medical University.

Fukushima Journal of Medical Science
|December 15, 2012
PubMed

Insights

Elevated serum uric acid (UA) levels are linked to ventricular tachycardia (VT) in patients with left ventricular hypertrophy (LVH). Higher UA levels independently predict VT occurrence, suggesting UA as a useful marker for arrhythmias.

Area of Science:

  • Cardiology
  • Nephrology
  • Internal Medicine

Background:

  • Elevated uric acid (UA) is associated with left ventricular hypertrophy (LVH).
  • LVH increases the risk of ventricular tachycardia (VT) and sudden cardiac death.
  • The relationship between serum UA levels and VT occurrence in LVH patients is unclear.

Purpose of the Study:

  • To investigate the association between serum UA levels and VT in patients with LVH.
  • To determine if UA is an independent predictor of VT in this population.

Main Methods:

  • 167 LVH patients (mean age 67.4 years) were analyzed using 24-hour Holter ECG.
  • Patients were categorized into VT (n=27) and Non-VT (n=140) groups.
  • Echocardiographic, renal function (BUN, creatinine, eGFR), and serum UA levels were compared.

Main Results:

  • No significant differences in echocardiographic parameters between groups.
  • VT group showed significantly higher BUN and UA levels (p < 0.01).
  • VT group had significantly lower eGFR (p < 0.01).
  • Multivariate analysis identified UA level as an independent predictor of VT (OR 1.61, p < 0.01).

Conclusions:

  • Serum UA level is a significant independent predictor of VT in patients with LVH.
  • Higher UA levels may indicate an increased risk of ventricular arrhythmias.
  • UA can serve as a valuable predictive marker for arrhythmias in LVH patients.
Abstract

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