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Liver in kala-azar.

P Aggarwal1, J P Wali, P Chopra

  • 1Department of Medicine, All India Institute of Medical Sciences, New Delhi.

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
|April 1, 1990
PubMed
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Kala-azar (visceral leishmaniasis) rarely leads to chronic liver disease or cirrhosis. Studies found no clinical, biochemical, radiological, or histopathological evidence of these conditions in affected patients.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Parasitology

Background:

  • Kala-azar, also known as visceral leishmaniasis, is a severe parasitic disease.
  • Liver involvement is a known complication of kala-azar, but the long-term consequences remain unclear.

Purpose of the Study:

  • To investigate the prevalence and nature of liver involvement in patients with kala-azar.
  • To determine if kala-azar can cause chronic liver disease, portal hypertension, or cirrhosis.

Main Methods:

  • Clinical examination of 60 kala-azar patients for signs of chronic liver disease.
  • Biochemical tests to assess liver function and detect hepatitis.
  • Radiological and radionuclide imaging to evaluate for portal hypertension and cirrhosis.
  • Liver histopathology in a subset of 18 patients.

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Main Results:

  • No patient exhibited clinical signs of chronic liver disease.
  • Approximately 25% of patients showed biochemical evidence of hepatitis.
  • Radiological and radionuclide studies did not reveal portal hypertension or cirrhosis in any patient.
  • Liver biopsies from 18 patients showed no evidence of chronic liver disease or cirrhosis.

Conclusions:

  • Kala-azar does not appear to cause chronic liver disease or cirrhosis.
  • Portal hypertension and cirrhosis are unlikely long-term consequences of kala-azar infection.