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Updated: May 16, 2026
Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis
Published on: May 17, 2015
Histologic analysis of chronic rejection in small bowel transplantation: mucosal and vascular alterations
Benjamin J Swanson1, Geoffrey A Talmon, James W Wisecarver
1Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.
Background:
Chronic rejection is a significant barrier to small bowel allograft survival. Although chronic rejection primarily involves vessels of the submucosa, serosa, and mesentery, some mucosal alterations have been suggested to be correlative.
Methods:
We retrospectively investigated explanted small bowel allografts for clinical characteristics and histological alterations in the mucosa, submucosa, and serosa.
Results:
Crypt epithelial mucin loss, submucosal fibrosis, and length of time to explant were all statistically associated with chronic rejection. Medium-sized and large-sized vessels of the serosa and mesentery preferentially demonstrated histologic changes of chronic rejection.
Conclusion:
These results further define chronic vascular rejection and the relationship between the mucosal changes and chronic rejection.
