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Updated: May 16, 2026

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
Published on: September 8, 2023
Relationship between bone mineral density and trabecular bone pattern in postmenopausal osteoporotic Brazilian women
Matheus Lima Oliveira1, Esio Fortaleza Nascimento Chaves Pedrosa, Adriana Dibo Cruz
1Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas-UNICAMP, P.O. Box 52, 13414-903, Piracicaba, São Paulo, Brazil, matheusoliveira@hotmail.com.
Objectives:
The aim of this study is to evaluate the relative efficacy of the mandibular trabecular bone in detecting osteoporotic-associated bone changes in Brazilian women.
Materials And Methods:
Seventy-three digital panoramic radiographs of healthy and osteoporotic postmenopausal women were used. Regions of interest were selected in the mandibular angle and body of the panoramic images, which were analyzed for fractal dimension (FD) and pixel intensity (PI). Statistical analysis evaluated the distribution pattern, compared normal with osteoporotic patients and the right with the left mandible, and assessed the relationship between FD and PI. The significance level was set at 0.05.
Results:
FD and PI values were significantly different (p < 0.05) between normal and osteoporotic patients for the right and left mandibular angle and for the left mandibular body. There was no significant difference (p > 0.05) between the right and left mandibular angle for FD and PI, but a significant difference (p < 0.05) was observed on the mandibular body for PI values. FD and PI values presented positive correlation.
Conclusions:
The mandibular trabecular bone was effective in detecting osteoporotic changes, with the exception of the right mandibular body.
Clinical Relevance:
Mandibular trabecular bone shows a promising attempt of accurate detection of osteoporotic changes in some regions of the jaws. Fractal analysis and pixel intensity had strong positive correlation.
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