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Updated: May 16, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
Role of cadherin-11 in synovial joint formation and rheumatoid arthritis pathology
Ce Dou1, Yanfei Yan, Shiwu Dong
1Department of Anatomy, Tissue Engineering Research Center of Chongqing, The Third Military Medical University, Gaotanyan Street No. 30, Chongqing, 400038, China.
Abstract:
Cadherin-11 is a classic cadherin adhesion molecule that mediates homophilic cell-to-cell adhesion. Cadherin-11 is involved in the function of embryonic development, tissue morphogenesis, tumor invasion and metastasis, and signal transduction. This review summarizes the function of cadherin-11 in synovial joint formation and rheumatoid arthritis (RA), including its relative function with bone and cartilage development and growth plate, synovial, and tendon formation. The role of cadherin-11 in RA is also discussed, both in fibroblasts inflammation and fibroblast-like synoviocyte (FLSs) migration and invasion. The potential of anti-cadherin-11 therapy for RA is introduced in comparison with the other current RA therapies.
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