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Related Concept Videos

Connective Tissue Cell Types01:22

Connective Tissue Cell Types

Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Inflammation01:38

Inflammation

Overview
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...

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Vitamin D and inflammation.

Uwe Querfeld1

  • 1Department of Paediatric Nephrology, Charité Children's Hospital, Augustenburger Platz 1, 13353, Berlin, Germany. uwe.querfeld@charite.de

Pediatric Nephrology (Berlin, Germany)
|December 15, 2012
PubMed
Summary
This summary is machine-generated.

Vitamin D deficiency is linked to cardiovascular disease and inflammation, particularly in chronic kidney disease (CKD) patients. Further trials are needed to confirm if vitamin D supplementation improves inflammation markers and cardiovascular outcomes in CKD.

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Area of Science:

  • Nephrology
  • Cardiology
  • Endocrinology

Background:

  • Vitamin D deficiency is increasingly recognized for its role in cardiovascular disease (CVD) pathogenesis and inflammation.
  • Low serum 25-hydroxyvitamin D levels define vitamin D deficiency, which is highly prevalent in chronic kidney disease (CKD) patients.
  • CKD is characterized by chronic low-grade inflammation, a key factor in disease progression and cardiovascular comorbidity.

Purpose of the Study:

  • To review clinical and experimental evidence linking vitamin D and inflammation.
  • To explore the potential role of vitamin D in the context of CKD and cardiovascular health.

Main Methods:

  • Review of existing clinical and experimental studies.
  • Analysis of the association between vitamin D levels, inflammation markers, and cardiovascular outcomes.

Main Results:

  • Evidence suggests a link between vitamin D deficiency and increased inflammation, particularly in the general population and CKD patients.
  • Chronic inflammation is a significant factor in CKD progression and associated cardiovascular issues.

Conclusions:

  • The relationship between vitamin D and inflammation warrants further investigation, especially in CKD.
  • Controlled clinical trials are necessary to determine if correcting vitamin D deficiency benefits inflammation markers and cardiovascular outcomes in CKD patients.