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Updated: May 16, 2026

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
06:44

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

Published on: September 8, 2017

Daxx regulates mitotic progression and prostate cancer predisposition

Pak Shing Kwan1, Chi Chiu Lau, Yung Tuen Chiu

  • 1Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Qld, Australia.

Carcinogenesis
|December 15, 2012
PubMed
Summary

Daxx is a novel inhibitor of the anaphase-promoting complex/cyclosome (APC/C) that is overexpressed in prostate cancer. This overexpression disrupts mitosis, potentially driving chromosome instability and cancer progression.

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