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Updated: May 16, 2026

Subcellular Fractionation for ERK Activation Upon Mitochondrial-derived Peptide Treatment
Published on: September 25, 2017
The emerging role of the mitochondrial-derived peptide humanin in stress resistance
Kelvin Yen1, Changhan Lee, Hemal Mehta
1USC Davis School of Gerontology, University of Southern California, Los Angeles, California 90089-0191, USA.
Abstract:
The discovery of humanin, a novel, mitochondrial-derived peptide, has created a potentially new category of biologically active peptide. As more research unravels the endogenous role of humanin as well as its potential pharmacological use, its role in stress resistance has become clearer. Humanin protects cells from oxidative stress, serum starvation, hypoxia, and other insults in vitro and also improves cardiovascular disease as well as Alzheimer's disease in vivo. In this review, we discuss the emerging role of humanin in stress resistance and its proposed mechanism of action.
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