Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stereotypes, Prejudice, and Discrimination02:55

Stereotypes, Prejudice, and Discrimination

Humans are very diverse and although we share many similarities, we also have many differences. The social groups we belong to help form our identities (Tajfel, 1974). These differences may be difficult for some people to reconcile, which may lead to prejudice toward people who are different. Prejudice is a negative attitude and feeling toward an individual based solely on one’s membership in a particular social group (Allport, 1954; Brown, 2010). Prejudice is common against people who are...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:
Ethics in Research01:56

Ethics in Research

Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transport Access for Ambulatory Care for Older People.

Irish medical journal·2026
Same author

Muscle Makers: A 10-Week Strength and Nutrition Program for Sarcopenia.

Irish medical journal·2025
Same author

The structure of liquid carbon elucidated by in situ X-ray diffraction.

Nature·2025
Same author

Consequences of the Crisis in Social Care for Older Hospital Inpatients with Frailty.

Irish medical journal·2025
Same author

Inpatient referrals to a specialist falls and syncope service: prevalence of STOPPFall FRIDs and review of deprescribing patterns.

European journal of clinical pharmacology·2024
Same author

Phase transition kinetics of superionic H<sub>2</sub>O ice phases revealed by Megahertz X-ray free-electron laser-heating experiments.

Nature communications·2024

Related Experiment Video

Updated: May 16, 2026

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

Ageism and clinical research.

R Briggs1, S Robinson, D O'Neill

  • 1Centre for Ageing, Neuroscience and the Humanities, Tallaght Hospital, Dublin.

Irish Medical Journal
|December 18, 2012
PubMed
Summary
This summary is machine-generated.

Older adults are underrepresented in clinical trials. A study of Dublin teaching hospitals found 13.7% of trials excluded participants by age, though less than international rates.

More Related Videos

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

Related Experiment Videos

Last Updated: May 16, 2026

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

Area of Science:

  • Gerontology
  • Clinical Research Ethics
  • Medical Research Methodology

Background:

  • Older adults are major healthcare consumers but often excluded from clinical trials.
  • This exclusion raises concerns about the applicability of trial results to real-world patient populations.
  • International research indicates a significant underrepresentation of elderly individuals in medical research.

Purpose of the Study:

  • To assess the prevalence of age-based exclusion criteria in research proposals submitted to Dublin teaching hospitals.
  • To compare the findings with international data on older adult participation in clinical trials.

Main Methods:

  • An audit of clinical research proposals submitted to the Research Ethics Committee (REC) at Trinity College Dublin (TCD) teaching hospitals from July 2008 to July 2011.
  • Recording of arbitrary upper age limits and other exclusion criteria that disproportionately affect older individuals.

Main Results:

  • Out of 226 trials, 13.7% (31 trials) excluded participants based solely on an arbitrary upper age limit.
  • Trials submitted by geriatricians (9.8%) did not exclude patients based on age.
  • Over 50% of neurology/psychiatry trials excluded patients by age, with a mean upper age limit of 69.2 years.
  • Cognitive function criteria further limited older adult participation in many trials.

Conclusions:

  • While a notable proportion of trials still use arbitrary age limits, older adult participation in this Irish center appears higher than international averages.
  • There is a need to increase awareness and promote the inclusion of older adults in clinical trials to ensure medication safety and efficacy across all consumer groups.
  • Greater input from geriatricians in the design, testing, and licensing of medicines is crucial for equitable healthcare.