Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Venous Thrombosis III: Interprofessional Care

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...

Venous Thrombosis IV: Nursing Management

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

Cellular Injury IV: Necrosis

Cellular Injury IV: Necrosis

Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...

Necrosis

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pathogenic XPO1 variants cause a dominant neurodevelopmental disorder.

Genetics in medicine : official journal of the American College of Medical Genetics·2025

Same author

The future of electronic health record-based research: Leveraging informatics in genetic counseling research.

Journal of genetic counseling·2025

Same author

An interactive web application for exploring human plasma and fibroblast metabolomics data from patients with inborn errors of metabolism.

bioRxiv : the preprint server for biology·2024

Same author

Deleterious, protein-altering variants in the transcriptional coregulator ZMYM3 in 27 individuals with a neurodevelopmental delay phenotype.

American journal of human genetics·2022

Same author

Access to clinically indicated genetic tests for pediatric patients with Medicaid: Evidence from outpatient genetics clinics in Texas.

Genetics in medicine : official journal of the American College of Medical Genetics·2022

Same author

Overcoming presynaptic effects of VAMP2 mutations with 4-aminopyridine treatment.

Human mutation·2020

Same journal

Effect of artificial intelligence on nursing documentation and patient safety.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2026

Same journal

Strategies for responding to anger from patients, relatives and carers.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2026

Same journal

Nurses' role in detecting early and subtle signs of patient deterioration in acute hospitals.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2026

Same journal

Pulse oximetry: exploring its role, limitations and challenges in clinical practice.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2026

Same journal

Anorexia nervosa: identification and management by non-specialist nurses.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2026

Same journal

Skin and soft tissue abscesses: assessment and management.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 16, 2026

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Published on: August 4, 2018

Warfarin-induced tissue necrosis: a case study.

Alison Crumbie¹, Heather Fisher, Grace Leedham

¹Windermere and Bowness Medical Practice, Cumbria. Alison.Crumbie@gp-a82046.nhs.uk

Nursing Standard (Royal College of Nursing (Great Britain) : 1987)

|December 18, 2012

Summary

This summary is machine-generated.

Warfarin-induced tissue necrosis is a rare but serious adverse drug reaction. Early diagnosis and prompt treatment are crucial for managing this complication and preventing severe outcomes.

More Related Videos

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel

Published on: June 29, 2015

Related Experiment Videos

Last Updated: May 16, 2026

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Published on: August 4, 2018

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel

Published on: June 29, 2015

Area of Science:

Pharmacology
Clinical Medicine
Adverse Drug Reactions

Background:

Warfarin is a widely used anticoagulant medication.
Tissue necrosis is a rare but severe adverse effect of warfarin therapy.

Observation:

A clinical case study highlights a patient experiencing warfarin-induced tissue necrosis.
This case underscores the critical need for prompt identification and management.

Findings:

Warfarin-induced tissue necrosis requires immediate medical attention.
Timely intervention can mitigate the severe consequences of this adverse drug reaction.

Implications:

Nurse prescribers must be vigilant for adverse drug reactions.
Awareness and prompt action are essential for patient safety in warfarin therapy.