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Related Experiment Video

Updated: May 16, 2026

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
11:15

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

Recent developments in uterine mesenchymal neoplasms.

Sarah Chiang1, Esther Oliva

  • 1Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Histopathology
|December 18, 2012
PubMed
Summary
This summary is machine-generated.

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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Diagnosing uterine mesenchymal neoplasms like smooth muscle and endometrial stromal tumors is challenging. Recent updates in criteria, immunohistochemical markers, and molecular genetics, including MED12 mutations, improve classification and offer potential therapeutic targets.

Area of Science:

  • Gynecologic Pathology
  • Surgical Pathology
  • Oncology

Background:

  • Uterine mesenchymal neoplasms, specifically smooth muscle and endometrial stromal tumors, are common but pose diagnostic challenges.
  • Advances in morphological criteria, staging, and immunohistochemical markers have refined tumor diagnosis and classification.
  • Distinguishing tumor cell necrosis from infarct-type necrosis and the role of p16 expression in leiomyosarcoma diagnosis require careful consideration.

Purpose of the Study:

  • To review current updates in the diagnosis and classification of uterine leiomyosarcomas and endometrial stromal sarcomas.
  • To highlight the impact of new molecular genetic findings on understanding tumor pathogenesis.
  • To discuss potential therapeutic targets based on emerging genetic information.

Main Methods:

Related Experiment Videos

Last Updated: May 16, 2026

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
11:15

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

  • Review of recent literature on uterine mesenchymal neoplasms.
  • Analysis of updated diagnostic criteria and immunohistochemical markers.
  • Examination of emerging genetic data, including MED12 mutations and gene rearrangements.

Main Results:

  • Improved diagnostic accuracy through updated criteria and immunohistochemistry.
  • Limited utility of p16 immunohistochemical expression in diagnosing leiomyosarcoma.
  • Controversial prognostic value of mitotic activity and necrosis in endometrial stromal sarcomas.
  • Identification of MED12 mutations in leiomyosarcomas and gene rearrangements in endometrial stromal sarcomas.

Conclusions:

  • Recent advancements enhance the diagnosis and classification of uterine mesenchymal tumors.
  • Molecular genetic findings are crucial for understanding sarcomagenesis and identifying therapeutic strategies.
  • Further research into genetic alterations may lead to novel treatments for these uterine neoplasms.