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Related Concept Videos

Microtubules in Signaling01:22

Microtubules in Signaling

The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...

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Related Experiment Video

Updated: May 16, 2026

Simple Detection of Primary Cilia by Immunofluorescence
08:07

Simple Detection of Primary Cilia by Immunofluorescence

Published on: May 15, 2020

Visualizing renal primary cilia.

James A Deane1, Elizabeth Verghese, Luciano G Martelotto

  • 1The Ritchie Centre, Australia. james.deane@monash.edu

Nephrology (Carlton, Vic.)
|December 18, 2012
PubMed
Summary
This summary is machine-generated.

Renal primary cilia, crucial for kidney function and disease, can now be visualized using advanced microscopy techniques. Understanding their structure and signaling is key to studying kidney diseases and repair mechanisms.

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Last Updated: May 16, 2026

Simple Detection of Primary Cilia by Immunofluorescence
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Published on: May 15, 2020

Volumetric Imaging and Analysis of Primary Cilia in Musculoskeletal Tissue using the ARL13B-CENTRIN-2 Mouse Model
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Optical Clearing and Imaging of Immunolabeled Kidney Tissue
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Optical Clearing and Imaging of Immunolabeled Kidney Tissue

Published on: July 22, 2019

Area of Science:

  • Nephrology
  • Cell Biology
  • Microscopy

Background:

  • Renal primary cilia are vital sensory organelles on kidney epithelial cells.
  • They play roles in epithelial differentiation, cystic kidney diseases, and renal repair.
  • Visualizing and understanding cilia composition is essential for kidney research.

Purpose of the Study:

  • To outline microscopy-based techniques for studying renal primary cilia.
  • To highlight the importance of cilia in kidney function and disease.

Main Methods:

  • Electron microscopy for high-resolution examination.
  • Fluorescence microscopy with new reagents and techniques for detailed analysis.
  • In situ imaging in kidney sections and in vitro studies using renal cell lines.

Main Results:

  • Established microscopy techniques allow detailed analysis of renal primary cilia structure and composition.
  • Both electron and fluorescence microscopy are valuable tools for cilia research.
  • In vitro cell culture systems offer accessible models for studying cilia.

Conclusions:

  • Microscopy techniques are indispensable for investigating renal primary cilia.
  • Understanding cilia is critical for advancing research in inherited kidney diseases and epithelial regeneration.