Related Experiment Video
Updated: May 16, 2026
09:43
Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
Published on: January 14, 2014
Malignant glioma with angiocentric features.
Jian-Qiang Lu1, Samir Patel, Beverly A Wilson
1Departments of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada. jian-qiang.lu@ualberta.ca
Journal of Neurosurgery. Pediatrics
|December 18, 2012
Summary
Angiocentric gliomas, typically benign brain tumors, can exhibit malignant features and recur after treatment. This case highlights a rare variant with glioblastoma-like characteristics and recurrence post-radiotherapy.
Area of Science:
- Neuro-oncology
- Pathology
- Radiation Oncology
Background:
- Angiocentric glioma is a recently identified, generally benign brain tumor.
- Its histogenesis remains unclear, and most cases show low mitotic activity correlating with a benign clinical course.
- However, rare instances of increased mitotic activity and even fatal outcomes have been reported.
Observation:
- A 15-year-old male presented with neurological deficits and a large right frontal lobe mass.
- Histopathology revealed a dual-component tumor: angiocentric glioma and glioblastoma-like tissue.
- The tumor recurred four months after gross-total resection and radiotherapy.
Findings:
- The recurrent tumor showed radiation-induced changes but retained angiocentric glioma features with reduced malignancy.
- This case, alongside prior reports, suggests angiocentric gliomas may possess a malignant variant or undergo malignant transformation.
- Malignant angiocentric gliomas demonstrate a propensity for recurrence.
Implications:
- Angiocentric gliomas with malignant features may require aggressive multimodal treatment.
- Surgical intervention followed by radiotherapy and chemotherapy is a potential therapeutic strategy for recurrent malignant angiocentric gliomas.
- Further research is needed to understand the biology and optimal management of aggressive angiocentric glioma variants.
