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Vitamins? The magic bullet against hepatitis C.

Hans L Tillmann¹

¹Gastroenterology/Division, Duke Clinical Research Institute Hepatology/Gastroenterology Research, Duke University, Durham, NC 27708, USA. hans.tillmann@duke.edu

Expert Review of Anti-Infective Therapy

|December 18, 2012

Summary

Vitamin B12 supplementation significantly enhanced sustained viral response rates in patients with chronic hepatitis C virus (HCV) infection when added to standard therapy. This finding supports vitamin B12

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Area of Science:

Hepatology
Virology
Nutritional Science

Background:

Hepatitis C virus (HCV) infection is a significant global health concern.
The role of vitamin B12 in HCV treatment has been suggested but not widely adopted.
Previous research indicated vitamin B12 may inhibit HCV in vitro and correlate with treatment response.

Purpose of the Study:

To evaluate the efficacy of vitamin B12 supplementation in improving treatment outcomes for chronic hepatitis C virus (HCV) infection.
To assess the impact of combined vitamin B12 and standard therapy on sustained viral response (SVR).

Main Methods:

A randomized trial was conducted involving patients with chronic HCV infection.
Standard therapy consisted of pegylated interferon plus ribavirin.
The experimental group received standard therapy combined with vitamin B12 supplementation.

Main Results:

The combination of vitamin B12 with pegylated interferon and ribavirin resulted in significantly better response rates at all time-points during therapy.
Patients receiving vitamin B12 showed improved rates of sustained viral response (SVR).

Conclusions:

Vitamin B12 supplementation appears to be a beneficial adjunct therapy for chronic hepatitis C virus (HCV) infection.
Further validation is needed, especially considering the advent of direct-acting antivirals for HCV treatment.