[Harm reduction centers ("CAARUD"): privileged places for warning signal detection in addictovigilance]

This study aims to describe profile and consumptions of subjects suffering a substance use disorder recruited in harm reduction centers (HRC, French "CAARUD", 156 included subjects in 7 centers) for the 2010 OPPIDUM survey, performed by the French CEIP-Addictovigilance network, in order to compare them to subjects included in ambulatory care centers (ACC, French "CSAPA", 3549 subjects included in 80 centers). Subjects recruited in HRC are younger and more precarious; they consume more illicit drugs, and prescription drugs known to be diverted (methylphenidate, morphine, ketamine,…). They consume less opiate maintenance treatment, antidepressants and psychotics. Obtaining and consumption modalities are also different (more illegal acquisitions for prescription drugs, more intravenous route use and less nasal route use in HRC). HRC are privileged places for watching substance use disorder (abuse, dependence) or prescription drugs diversions, and for early warning signal detection in addictovigilance.