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Published on: January 26, 2018
Efficacy and safety of deep sclerectomy in childhood glaucoma in Saudi Arabia
Saleh Ali Al-Obeidan1, Essam El-Din Ahmed Osman, Ahmed Salah Dewedar
1Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi ArabiaNational Guard Hospital, Riyadh, Saudi ArabiaDepartment of Ophthalmology, University of Ghent, Ghent, Belgium.
Insights
Deep sclerectomy effectively reduces intraocular pressure in childhood glaucoma patients. This surgical approach offers a favorable safety profile compared to traditional glaucoma surgeries.
Area of Science:
- Ophthalmology
- Pediatric Surgery
Background:
- Childhood glaucoma presents unique challenges requiring effective surgical interventions.
- Nonpenetrating deep sclerectomy (NPDS) and penetrating deep sclerectomy (PDS) are surgical options for managing pediatric glaucoma.
Discussion:
- Deep sclerectomy, with or without intraoperative mitomycin C, demonstrates significant intraocular pressure reduction in children.
- The study compared NPDS and PDS, noting a trend towards greater IOP reduction with NPDS, though not statistically significant.
- The procedure exhibited a favorable safety profile, with minimal intraoperative and early postoperative complications.
Key Insights:
- Deep sclerectomy achieved a complete success rate of 79.7% and an overall success rate of 82.4% in managing childhood glaucoma.
- Mean intraocular pressure decreased from 31.9 mmHg preoperatively to 11.5 mmHg postoperatively.
- The surgical technique avoids serious complications often associated with trabeculotomy or combined trabeculotomy-trabeculectomy.
Outlook:
- Deep sclerectomy represents a viable and safe surgical alternative for childhood glaucoma.
- Further research may explore long-term outcomes and refine surgical techniques for pediatric glaucoma management.
Purpose:
To evaluate the efficacy and safety of deep sclerectomy in childhood glaucoma.
Methods:
A prospective cohort of 120 children presenting with glaucoma to King Abdul Aziz University Hospital (KAUH) was subjected to nonpenetrating deep sclerectomy surgery (NPDS). Eventually, 57 patients had macro perforation and converted to penetrating deep sclerectomy (PDS). Intra-operative mitomycin C (MMC) 0.2 mg/ml was used in all patients. Pre- and postintervention glaucoma indices were assessed. Complete success rate (CSR) was identified as achieving an end-point of intraocular pressure <21 without any antiglaucoma medications. Data were analysed to compare pre- and postintervention changes and to compare both procedures.
Results:
After follow-up of 35.8 (34.5) months, NPDS procedure went smooth in 74 eyes of 63 patients. The complete success rate was 79.7%, whereas the overall success rate was 82.4%. Thirteen cases failed. The probability to survive was 74.6% after the 12th month. The mean intraocular pressure (IOP) went down to 11.5 ± 3.0 mmHg compared to 31.9 mmHg preoperatively. Comparing cases with NPDS to those with PDS, the magnitude of IOP reduction (15.8) was higher than that of the PDS (14.8); however, this difference was not statistically significant (p = 0.259). Apart from involuntary perforation of trabeculodescemetic window (TDW), neither intra-operative nor early postoperative complications were observed.
Conclusions:
Deep sclerectomy in childhood glaucoma can effectively reduce the IOP, without the occurrence of serious complications that are commonly seen after trabeculotomy or combined trabeculotomy trabeculectomy.
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