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Related Concept Videos

Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Internal Anatomy of the Kidney01:12

Internal Anatomy of the Kidney

The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Kidney Structure01:45

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Anatomy of the Genitourinary System I: Kidneys and Ureters01:11

Anatomy of the Genitourinary System I: Kidneys and Ureters

The upper urinary system comprises two kidneys and two ureters, which are crucial in filtering blood and forming urine.KidneysLocation and Structure:The kidneys are two bean-shaped organs positioned behind the peritoneum on either side of the spine.Kidneys are between the 12th thoracic (T12) and the 3rd lumbar (L3) vertebrae.The position of the liver causes the right kidney to sit slightly lower than the left.Protective Layers:Each kidney is enveloped in a tough, fibrous membrane called the...

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Related Experiment Video

Updated: May 16, 2026

Development of Human Renal Tubular Epithelial Cell Primary Cultures in Monolayers and Three-Dimensional Conditions
06:32

Development of Human Renal Tubular Epithelial Cell Primary Cultures in Monolayers and Three-Dimensional Conditions

Published on: June 13, 2025

Telocytes in the human kidney cortex.

Guisheng Qi1, Miao Lin, Ming Xu

  • 1Department of Urology, Fudan University Zhongshan Hospital, Shanghai, China.

Journal of Cellular and Molecular Medicine
|December 18, 2012
PubMed
Summary
This summary is machine-generated.

Telocytes (TCs), a novel cell type, were identified in the human kidney interstitium. These renal TCs share characteristics with those in other organs, but their specific kidney functions require further investigation.

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Last Updated: May 16, 2026

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Isolation of Primary Human Proximal Tubule Epithelial Cells and Their Use in Creating a Microphysiological Model of the Renal Proximal Tubule
07:06

Isolation of Primary Human Proximal Tubule Epithelial Cells and Their Use in Creating a Microphysiological Model of the Renal Proximal Tubule

Published on: May 9, 2025

Area of Science:

  • Nephrology
  • Cell Biology
  • Histology

Background:

  • Renal interstitial cells are crucial for kidney function and disease.
  • Telocytes (TCs) are a recently discovered type of interstitial cell found in various organs.
  • The presence and role of TCs in the kidney interstitium remain largely uncharacterized.

Purpose of the Study:

  • To investigate the presence and characteristics of telocytes (TCs) in the human kidney cortex interstitium.
  • To determine the phenotype and localization of renal TCs.

Main Methods:

  • Primary cell culture of human kidney tissue.
  • Transmission electron microscopy (TEM) for ultrastructural analysis.
  • In situ immunohistochemistry (IHC) for marker identification.

Main Results:

  • Telocytes (TCs) were successfully identified and cultured from the human kidney cortex interstitium.
  • Renal TCs exhibited positive staining for CD34, CD117, and vimentin.
  • TCs were observed in the interstitial space, partially enveloping tubules and blood vessels, with morphology consistent with TCs in other tissues.

Conclusions:

  • Telocytes (TCs) are present in the human kidney cortex interstitium.
  • Renal TCs possess a distinct phenotype and morphology similar to TCs in other organs.
  • Further research is needed to elucidate the specific functions of renal TCs in kidney physiology and pathology.