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Rasamsonia argillacea pulmonary and aortic graft infection in an immune-competent patient
Jeffrey B Doyon1, Deanna A Sutton, Pierre Theodore
1Division of Thoracic Surgery, University of California, San Francisco, San Francisco, California, USA.
Abstract:
Rasamsonia argillacea (formerly known as Geosmithia argillacea) is a fungus recently recognized as a pathogen of immunocompromised patients. Here we report the first case of Rasamsonia infection in an immunocompetent host, presenting as a pulmonary and aortic graft infection. Its morphological similarity to nonpathogenic Penicillium species delayed the diagnosis and initiation of appropriate treatment.
Insights
Rasamsonia argillacea, a fungus previously known as Geosmithia argillacea, can infect even healthy individuals. This report details the first such case, highlighting diagnostic challenges due to its resemblance to non-pathogenic fungi.
Area of Science:
- Medical Mycology
- Infectious Diseases
Background:
- Rasamsonia argillacea (formerly Geosmithia argillacea) is an emerging fungal pathogen primarily affecting immunocompromised individuals.
- Fungal infections pose a significant threat, particularly in clinical settings.
Observation:
- This study documents the first reported case of Rasamsonia argillacea infection in an immunocompetent host.
- The infection presented as a severe pulmonary and aortic graft involvement.
Findings:
- Morphological similarity between Rasamsonia argillacea and nonpathogenic Penicillium species complicated early diagnosis.
- Delayed diagnosis led to a delay in initiating appropriate antifungal treatment.
Implications:
- This case expands the known host range for Rasamsonia argillacea, indicating potential risk even in immunocompetent populations.
- Highlights the need for increased awareness and improved diagnostic methods for identifying Rasamsonia infections.
- Emphasizes the importance of considering rare fungal pathogens in complex clinical presentations, even in non-immunocompromised patients.
