Addressing the relationship between cardiac hypertrophy and ischaemic stroke: an observational study
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Published on: June 14, 2016
Chaturaka Rodrigo1, Sajitha Weerasinghe, Vijayabala Jeevagan
1Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. chaturaka.rodrigo@gmail.com.
Insights
Left ventricular hypertrophy (LVH) is a significant risk factor for stroke. This study found a high prevalence of LVH in Sri Lankan patients with ischemic stroke, indicating a need for screening evaluations.
Area of Science:
- Cardiology
- Neurology
- Medical Imaging
Background:
- Left ventricular hypertrophy (LVH) is an established risk factor for major cardiovascular events, including stroke.
- Echocardiography provides a viable method for assessing LVH, complementing cardiac MRI.
Purpose of the Study:
- To determine the prevalence of LVH in patients presenting with ischemic stroke in Sri Lanka.
- To quantify LVH using echocardiography in a Sri Lankan cohort.
Main Methods:
- A prospective, hospital-based study was conducted at the National Hospital of Sri Lanka over six months.
- Echocardiography was used to assess left ventricular mass index in patients with ischemic stroke.
Main Results:
- Out of 55 ischemic stroke patients, 38 had their height and weight measured for LVH assessment.
- A high prevalence of LVH was observed, with 76.3% of evaluated patients having LVH, and 50% exhibiting severe hypertrophy.
Conclusions:
- The study highlights a significantly high prevalence of LVH among Sri Lankan ischemic stroke patients.
- Given LVH's role in stroke and available treatments, population screening cost-effectiveness warrants evaluation.
Introduction:
Research over the last decade has recognized left ventricular hypertrophy as a risk factor for major cardiovascular events including stroke. While cardiac magnetic resonance imaging is the best modality to quantify left ventricular hypertrophy, echocardiographic calculation of left ventricular mass index is a reasonable alternative.
Methods:
We carried out a hospital based prospective study to identify the prevalence of left ventricular hypertrophy, assessed using echocardiography, in patients presenting with ischaemic strokes. This is the first study that attempted to quantify this issue in a cohort of Sri Lankan patients. The study was carried out in the National Hospital of Sri Lanka over a period of 6 months.
Results:
A total of 55 patients (44 males, 80%) (mean age: 62.3, range: 48-82 years) with ischaemic strokes were studied. Of them, only 38 could be mobilized to measure the height and weight to calculate the left ventricular mass index. Of the rest, only one person had the electrocardiographic criteria for left ventricular hypertrophy. Of the 38 patients evaluated, 29 (76.3%) had left ventricular hypertrophy while 19 (50%) had severe hypertrophy.
Discussion And Conclusions:
The rates of left ventricular hypertrophy reported in similar studies in other countries vary between 25-62%. Given the high prevalence of left ventricular hypertrophy reported in this study and its recognition as a risk factor for stroke recently, together with the availability of effective treatment for risk reduction, the cost effectiveness of population screening should be evaluated. Further studies are planned in this regard.
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