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Related Concept Videos

Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
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Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
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Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

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Related Experiment Video

Updated: May 16, 2026

Visualization of Neutrophil Extracellular Traps in Mesenteric Venules After Mesenteric Ischemia-Reperfusion Injury via Intravital Microscopy
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Published on: September 27, 2024

Thrombomodulin in sepsis.

M Levi1, T Van Der Poll

  • 1Department of Vascular Medicine and Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands. m.m.levi@amc.uva.nl

Minerva Anestesiologica
|December 18, 2012
PubMed
Summary
This summary is machine-generated.

Thrombomodulin (TM) downregulation in sepsis impairs protein C activation, worsening coagulation and inflammation. Soluble TM administration shows promise in preclinical and early clinical studies for sepsis-associated complications.

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Last Updated: May 16, 2026

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Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood
07:08

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

Published on: September 5, 2017

Area of Science:

  • Biochemistry
  • Immunology
  • Critical Care Medicine

Background:

  • Thrombomodulin (TM) is crucial for the protein C system, regulating coagulation and inflammation.
  • Sepsis leads to decreased endothelial TM expression, impairing protein C activation and exacerbating disease.
  • TM possesses intrinsic immunomodulatory properties affecting neutrophils, complement, and cytokines.

Purpose of the Study:

  • To evaluate the therapeutic potential of soluble thrombomodulin in sepsis.
  • To investigate TM's role in modulating coagulation and inflammatory responses during sepsis.

Main Methods:

  • Preclinical studies in experimental sepsis models.
  • Analysis of initial clinical trials involving patients with disseminated intravascular coagulation, including sepsis patients.

Main Results:

  • Soluble TM administration improved coagulation abnormalities in sepsis models.
  • Treatment with soluble TM ameliorated inflammatory responses and restored organ function in preclinical studies.
  • Early clinical data suggest recombinant soluble TM benefits coagulation and organ failure in patients with disseminated intravascular coagulation and sepsis.

Conclusions:

  • Downregulation of thrombomodulin is a key factor in sepsis pathogenesis.
  • Soluble thrombomodulin represents a potential therapeutic strategy for sepsis and its complications.
  • Further clinical investigation of soluble TM in sepsis is warranted.